Discussion around statin discontinuation in older adults and patients with wasting diseases.
Statin discontinuation (as well as essential dose reduction) has been associated with higher risk for CVD events and death in patients with coronary artery disease (CAD), and especially in patients after acute coronary syndrome, in which the instability of atheroma plaque might appear. However, research on the causes of discontinuation of statins in routine practiceis still very limited.
Statin discontinuation may concern the patients with complete statin intolerance, as well as patients with cancer, palliative care patients, patients with cachexia, but also elderly patients, and primary CV prevention individuals, in which the risk of statin-related side effects (mainly associated with new-onset diabetes) might exceed the benefits (especially with subjects with risk factors of diabetes well adhered to non-pharmacological therapy). Statin discontinuation (as well as essential dose reduction) has been associated with higher risk for CVD events and deathin patients with coronary artery disease (CAD), and especially in patients after acute coronary syndrome, in which the instability of atheroma plaque might appear. However, researchon the causes of discontinuation of statins in routine practiceis still very limited.

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