Effect of curcuminoids on oxidative stress: A systematic review and meta-analysis of randomized controlled trials.
The aim of the meta-analysis was to evaluate the efficacy of purified curcuminoids supplementation on plasma activities of superoxide dismutase (SOD), catalase and glutathione (GSH) and lipid peroxides as parameters of oxidative stress. Seven randomized controlled trials were finally selected for the meta-analysis.
Abstract: The aim of the meta-analysis was to evaluate the efficacy of purified curcuminoids supplementation on plasma activities of superoxide dismutase (SOD), catalase and glutathione (GSH) and lipid peroxides as parameters of oxidative stress. Seven randomized controlled trials were finally selected for the meta-analysis. There was a significant increase of serum SOD activities after curcuminoids supplementation (weighted mean difference [WMD]: 1.15 U/mL, 95% confidence interval [CI]: 0.49–1.82, p = 0.0007). In a subgroup analysis, no significant effects was observed in the subset of studies administering curcuminoids for <6 weeks (WMD: 0.75 U/mL, 95%CI: −0.56–2.05, p = 0.26), but a significant increase of SOD activities was found with supplementation duration ≥6 weeks (WMD: 1.46 U/mL, 95%CI: 0.60–2.32, p = 0.0009). The curcuminoids significantly reduced serum lipid peroxides (WMD: −6.35 nmol/mL, 95%CI: −11.06 to −1.64, p = 0.008), increased GSH concentrations (WMD: 5.39 µg/mL, 95%CI: 1.17–9.60, p = 0.01), and catalase activity (WMD: 51.78 U/mL, 95%CI: 15.71–87.85, p = 0.005). This meta-analysis showed a significant effect of curcuminoids in elevating serum SOD and catalase activities, GSH concentrations, and reduction of serum lipid peroxides.

Abbreviations: ARE, antioxidant response element; BMI, body mass index; CI, confidence interval; CMA, comprehensive meta-analysis; CVD, cardiovascular disease; HDL-C, high-density lipoprotein cholesterol; hs-CRP, high-sensitivity C-reactive protein; GSH, glutathione; LDL-C, low-density lipoprotein cholesterol; PLGA, polylactic-co-glycolic acid; PRISMA, preferred reporting items for systematic reviews and meta-analysis; SOD, superoxide dismutase; SDs, standard deviations; WMD, weighed mean difference.

Keywords: Superoxide dismutase; SOD; Curcumin supplementation; Curcuma longa; Oxidative stress; Curcuminoids.

The full text of the meta-analysis is available here: [Full Text_Curcuminods]
 
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