Effects of statins on lipid profile in chronic kidney disease patients: a meta-analysis of randomized controlled trials
Chronic kidney disease (CKD) is defined as a glomerular filtration rate (GFR)560 mL/min/1.73 m2. The incidence of CKD is rising worldwide, and CKD is associated with increased cardiovascular (CV) morbidity and mortality. CKD with significant albuminuria/proteinuria is frequently associated with substantial alterations of serum lipid levels, most often with elevation in low-density lipoprotein (LDL) particle numbers and triglycerides (TG), and a reduction in high-density lipoprotein cholesterol (HDL-C)2. CKD increases the risk for end stage renal disease (ESRD), atherosclerotic disease, vascular calcification, as well as myocardial infarction, ischemic stroke and death. Even patients in the early stages of CKD are at increased risk of cardiovascular disease (CVD) and a large number of patients with CKD die before developing ESRD.
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