Lipoprotein(a) Levels in Patients With Abdominal Aortic Aneurysm: A Systematic Review and Meta-Analysis.
Circulating markers relevant to the development of abdominal aortic aneurysm (AAA) are currently required. Lipoprotein(a) (Lp(a)) is considered a candidate marker associated with the presence of AAA. The present meta-analysis aimed to evaluate the association between circulating Lp(a) levels and the presence of AAA.
BACKGROUND: Circulating markers relevant to the development of abdominal aortic aneurysm (AAA) are currently required. Lipoprotein(a) (Lp(a)) is considered a candidate marker associated with the presence of AAA.

PURPOSE: The present meta-analysis aimed to evaluate the association between circulating Lp(a) levels and the presence of AAA.

METHODS: A PubMed-based search was conducted up to April 30, 2015 to identify the studies focusing on Lp(a) levels in patients with AAA and controls. Quantitative data synthesis was performed using a random-effects model, with standardized mean difference (SMD) and 95% confidence interval (CI) as summary statistics.

RESULTS: Overall, 9 studies with 1564 patients were included. The studies were published between 1988 and 2013, and were conducted in Sweden, USA, UK, Austria, Italy, and New Zealand. The mean age of the patients ranged from 56-73.5 years. The patients with AAA were found to have a significantly higher level of Lp(a) compared with the controls (SMD: 0.87, 95% CI: 0.41, 1.33, p < 0.001). This result remained robust in the sensitivity analysis and its significance was not influenced after omitting each of the included studies.

CONCLUSIONS: The present meta-analysis found a higher level of circulating Lp(a) in patients with AAA compared with controls. High Lp(a) levels can be associated with the presence of AAA and Lp(a) may be a marker in screening for AAA. Further studies are needed to establish the clinical utility of measuring Lp(a) in the prevention and management of AAA.

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