Lipoprotein(a) - We Know So Much Yet Still Have Much to Learn...
Lipoprotein(a) (Lp[a]) has been identified as an independent, causal risk factor for cardiovascular disease(CVD). Lp(a) has a structure similar to low-density lipopro-tein (LDL) in its lipid core composition in addition to a molecule of apolipoprotein B100 (apoB), but also contains a unique glycoproteine - apo(a), with strong structural homology with plasminogen.
Lipoprotein(a) (Lp[a]) has been identified as an independent, causal risk factor for cardiovascular disease (CVD). Lp(a) has a structure similar to low‐density lipoprotein (LDL) in its lipid core composition in addition to a molecule of apolipoprotein B100 (apoB), but also contains a unique glycoprotein - apo(a), with strong structural homology with plasminogen. Apo(a) contains anything from 3, to more than 50 identically repeated plasminogen‐like kringle IV domains, which gives rise to the heterogeneity in isoform size reported in the population. There is a general inverse correlation between the size of the apo(a) isoform and the Lp(a) plasma concentration. The variation in the concentration of Lp(a) is primarily controlled by the level of synthesis rather than catabolism, with as much as 90% of the variation being genetically determined based on variation in the gene encoding apo(a) (LPA) located on chromosome 6q26‐27. (...)

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