Other important papers
Please find the information and links to the other importatant papers of LBPMC Group members
 
Bioresorbable scaffold - A magic bullet for the treatment of coronary artery disease?
The purpose of this review is to present the theoretical rationale for the use of BRS and to outline the clinical outcomes associated with their use in terms of data obtained from RCTs, clinical trials, registries and real life use. We have also tried to answer all questions on this intervention based on available data, with a focus on ABSORB BVS (Abbott Vascular, Santa Clara, USA). We consider that this new technology can be the “magic bullet” to treat coronary artery disease.
 
Lipoprotein(a) - We Know So Much Yet Still Have Much to Learn...
Lipoprotein(a) (Lp[a]) has been identified as an independent, causal risk factor for cardiovascular disease(CVD). Lp(a) has a structure similar to low-density lipopro-tein (LDL) in its lipid core composition in addition to a molecule of apolipoprotein B100 (apoB), but also contains a unique glycoproteine - apo(a), with strong structural homology with plasminogen.
 
Discussion around statin discontinuation in older adults and patients with wasting diseases.
Statin discontinuation (as well as essential dose reduction) has been associated with higher risk for CVD events and death in patients with coronary artery disease (CAD), and especially in patients after acute coronary syndrome, in which the instability of atheroma plaque might appear. However, research on the causes of discontinuation of statins in routine practiceis still very limited.
 
Association of Serum Lipids and Coronary Heart Disease in Contemporary Observational Studies.
The use of statins increased among US adults with high coronary heart disease (CHD) risk following publication of the 2001 cholesterol treatment guidelines.
 
Is statin-modified reduction in lipids the most important preventive therapy for cardiovascular disease? A pro/con debate.
he most prescribed medications in the world are statins, lipid modifiers that have been available for over 25 years and amongst the most investigated of all drug classes. With over a million patient years of trial data and publications in the most prestigious medical journals, it is remarkable that quite so much debate remains as to their place in healthcare.
 
Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel.
The aim of this position paper was to suggest a unified definition of statin intolerance, and to complement the recent EAS statement on SAMS, where the pathophysiology, diagnosis and the management were comprehensively presented.
 
Patient-Level Discordance in Population Percentiles of the TC/HDL-C Ratio Compared with LDL-C and Non-HDL-C: The Very Large Database of Lipids Study (VLDL-2B).
The total cholesterol to high-density lipoprotein cholesterol (TC/HDL-C) ratio, estimated low-density lipoprotein cholesterol (LDL-C), and non-HDL-C are routinely available from the standard lipid profile. We aimed to assess the extent of patient-level discordance of TC/HDL-C with LDL-C and non-HDL-C because discordance suggests the possibility of additional information.
 
Effect of garlic on plasma lipoprotein(a) concentrations: A systematic review and meta-analysis of randomized controlled clinical trials.
Garlic can play an essential role in the prevention of atherosclerosis, but the research addressing the effect of garlic on the concentration of lipoprotein(a) [Lp(a)] has not been fully demonstrated. The aim of this study was to assess the effect of garlic on plasma Lp(a) concentrations through systematic review of literature and meta-analysis of available randomized controlled trials.
 
Relationship of the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio to the remainder of the lipid profile: The Very Large Database of Lipids-4 (VLDL-4) study.
Triglyceride to HDL-C ratio becomes relevant in setting of obesity and insulin resistance. High TG/HDL-C ratio is associated with high remnant-lipoprotein cholesterol and LDL density. RLP-C and LDL density may be mediators of cardiovascular risk conferred by TG/HDL-C ratio.
 
A systematic review and meta-analysis of the impact of Spirulina supplementation on plasma lipid concentrations.
Many studies suggested that blue-green microalga Spirulina might be a potent hypolipidemic agent. A meta-analysis showed a significant effect of Spirulina supplementation in TC, LDL-C, TGs plasma levels reducing. A significant increase of HDL-C was also observed after Spirulina supplementation. The impact of Spirulina on plasma lipids concentrations was independent of administered dose. Spirulina might be a valuable nutraceutical in dyslipidemic patients.
 
Familial hypercholesterolaemia: A global call to arms.
Familial Hypercholesterolaemia (FH) is the commonest autosomal co-dominantly inherited condition affecting man. It is caused by mutation in one of three genes, encoding the low-density lipoprotein (LDL) receptor, or the gene for apolipoprotein B (which is the major protein component of the LDL particle), or in the gene coding for PCSK9 (which is involved in the degradation of the LDL-receptor during its cellular recycling).
 
Effects of supplementation with green tea catechins on plasma C-reactive protein concentrations: A systematic review and meta-analysis of randomized controlled trials.
Promising experimental and clinical trials suggest that green tea decreases the inflammatory process in cardiometabolic diseases, but evidence from epidemiologic studies about the effects on plasma C-reactive protein (CRP) seems inconsistent and ambiguous. Therefore, the aim of this meta-analysis was to evaluate the effects of green tea supplementation on plasma CRP concentrations.
 
Effect of sour tea (Hibiscus sabdariffa L.) on arterial hypertension: a systematic review and meta-analysis of randomized controlled trials.
Hibiscus sabdariffa L. is a tropical wild plant rich in organic acids, polyphenols, anthocyanins, polysaccharides, and volatile constituents that are beneficial for the cardiovascular system. Hibiscus sabdariffa beverages are commonly consumed to treat arterial hypertension, yet the evidence from randomized controlled trials (RCTs) has not been fully conclusive. Therefore, we aimed to assess the potential antihypertensive effects of H. sabdariffa through systematic review of literature and meta-analysis of available RCTs
 
Lipids, blood pressure and kidney update 2014
This paper is an effort to review all the most important studies and guidelines in the topics of lipid, blood pressure and kidney published in 2014.
 
Effect of curcuminoids on oxidative stress: A systematic review and meta-analysis of randomized controlled trials.
The aim of the meta-analysis was to evaluate the efficacy of purified curcuminoids supplementation on plasma activities of superoxide dismutase (SOD), catalase and glutathione (GSH) and lipid peroxides as parameters of oxidative stress. Seven randomized controlled trials were finally selected for the meta-analysis.
 
Lipid profile and glucose changes after supplementation with astaxanthin: a systematic review and meta-analysis of randomized controlled trials.
Many studies have shown that oral supplementation with astaxanthin may be a novel potential treatment for inflammation and oxidative stress in cardiovascular diseases, but evidence of the effects on lipid profile and glucose is still inconclusive. Therefore, we performed a meta-analysis to evaluate the efficacy of astaxanthin supplementation on plasma lipid and glucose concentrations.
 
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