Statins in patients with chronic kidney disease – an attempt at recommendations
Chronic kidney disease (CKD) is associated with cardiovascular disease (CVD) even in the early stages of the disease and a large number of patients die from CVD before developing advanced CKD. Beyond established risk factors (e.g. hypertension, dyslipidaemia, obesity, smoking and diabetes) these patients might also have additional predictors of CVD such as proteinuria, electrolyte imbalances, inflammation, oxidative stress and endothelial dysfunction that amplify vascular risk. Dyslipidaemia is an independent risk factor for the progression of CKD. CKD with significant proteinuria is commonly associated with substantial alteration of serum lipid levels. The most common changes being lowered high density lipoprotein cholesterol (HDL-C) levels and elevated level of triglycerides (TG); hypercholesterolemia per se might be present in around 50% of patients on dialysis.
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